New pooled data presented at ENDO 2025 (July 14, 2025) show that GLP-1 receptor agonists increased total testosterone levels in men with obesity compared to controls. This supports the connection between metabolic health and androgen status, suggesting that weight-loss pharmacotherapy may help restore endogenous testosterone. (ENDO 2025, Press Release)

DHEA and Sex Hormones in Postmenopausal Women

A recent systematic review and meta-analysis of randomized controlled trials found that DHEA supplementation significantly raised circulating estradiol and testosterone in postmenopausal women. This underscores its potential as a physiologic precursor when modulating the estrogen/androgen balance in clinical practice. (BMC Women’s Health. Published July 4, 2025)