Pygeum (Pygeum africanum / Prunus africana)
Pygeum africanum, derived from the bark of the African plum tree, is a lipophilic extract used for more than five decades in European urology to manage the lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH). Its active constituents — phytosterols, pentacyclic triterpenes, and ferulic acid esters — give it a pharmacology distinct from […]
Real-World Evidence Reinforces Safety and Effectiveness of Testosterone Therapy in Largest Cohort to Date
As Men’s Health Month brings renewed attention to androgen optimization, a newly published longitudinal cohort study of over 9,000 men treated for testosterone deficiency offers BHRT providers the most robust real-world dataset on testosterone therapy (TTh) outcomes to date. Published in the April 2026 issue of World Journal of Men’s Health, Clift and colleagues — […]
Early Hormone Therapy Significantly Reduces Osteoporosis and Fracture Risk in Postmenopausal Women
In this month’s update, a large real-world propensity-matched study presented at the 2026 Annual Meeting of the American Academy of Orthopaedic Surgeons found that postmenopausal women who initiated hormone replacement therapy within one year of their menopause diagnosis faced a significantly lower risk of osteoporosis over a five-year follow-up compared to non-users (OR 1.18 favoring […]
Melatonin
Melatonin is far more than a sleep supplement. Produced in the pineal gland, gut, immune cells, and within the mitochondria of virtually every cell, it functions as a master circadian regulator, potent antioxidant, and key participant in metabolic, immune, and reproductive health. For BHRT providers, its clinical significance extends well beyond sleep support: melatonin production […]
Hormone Therapy Amplifies Tirzepatide Weight Loss in Postmenopausal Women
A Mayo Clinic retrospective cohort study published in The Lancet Obstetrics, Gynaecology, & Women’s Health in January 2026 found that postmenopausal women using concurrent hormone therapy lost 35% more weight on tirzepatide than those on tirzepatide alone (–19.2% vs. –14.0% total bodyweight loss; p=0.0023), with 45% of hormone therapy users achieving ≥20% total bodyweight loss […]
Testosterone Predicts Cognitive-Motor Brain Performance in Men and Women
A neuroimaging study from York University adds compelling evidence that testosterone supports brain function well beyond reproductive health — specifically in the neural networks that integrate thought and movement. Among 36 healthy working-age adults (18 female), researchers measured salivary hormone levels and used MRI imaging alongside touchscreen-based visuomotor tasks, including a cognitively demanding “cognitive-motor integration” […]
HRT as a Geroprotective Longevity Intervention
A paradigm-shifting perspective published in Aging and Disease reframes hormone replacement therapy from symptomatic relief to a fundamental geroprotective intervention capable of influencing biological aging mechanisms in women. The comprehensive review by Rabinovici et al. proposes that HRT mechanistically addresses all 12 hallmarks of aging and emphasizes that ovarian endocrine decline represents one of the […]
HRT Safety in BRCA Mutation Carriers
A groundbreaking study presented at the December 2025 San Antonio Breast Cancer Symposium challenges longstanding concerns about menopausal hormone therapy (MHT) in women with BRCA mutations. The matched prospective analysis of 1,352 menopausal women (676 matched pairs) with BRCA1 or BRCA2 mutations found that MHT use was inversely associated with breast cancer risk over a […]
Starting Hormone Therapy Sooner May Save Lives, Study Finds
Testosterone & Obesity Pharmacotherapy
New pooled data presented at ENDO 2025 (July 14, 2025) show that GLP-1 receptor agonists increased total testosterone levels in men with obesity compared to controls. This supports the connection between metabolic health and androgen status, suggesting that weight-loss pharmacotherapy may help restore endogenous testosterone. (ENDO 2025, Press Release) DHEA and Sex Hormones in […]
