Melatonin
Melatonin is far more than a sleep supplement. Produced in the pineal gland, gut, immune cells, and within the mitochondria of virtually every cell, it functions as a master circadian regulator, potent antioxidant, and key participant in metabolic, immune, and reproductive health. For BHRT providers, its clinical significance extends well beyond sleep support: melatonin production […]
HRT as a Geroprotective Longevity Intervention
A paradigm-shifting perspective published in Aging and Disease reframes hormone replacement therapy from symptomatic relief to a fundamental geroprotective intervention capable of influencing biological aging mechanisms in women. The comprehensive review by Rabinovici et al. proposes that HRT mechanistically addresses all 12 hallmarks of aging and emphasizes that ovarian endocrine decline represents one of the […]
HRT Safety in BRCA Mutation Carriers
A groundbreaking study presented at the December 2025 San Antonio Breast Cancer Symposium challenges longstanding concerns about menopausal hormone therapy (MHT) in women with BRCA mutations. The matched prospective analysis of 1,352 menopausal women (676 matched pairs) with BRCA1 or BRCA2 mutations found that MHT use was inversely associated with breast cancer risk over a […]
Starting Hormone Therapy Sooner May Save Lives, Study Finds
Testosterone & Obesity Pharmacotherapy
New pooled data presented at ENDO 2025 (July 14, 2025) show that GLP-1 receptor agonists increased total testosterone levels in men with obesity compared to controls. This supports the connection between metabolic health and androgen status, suggesting that weight-loss pharmacotherapy may help restore endogenous testosterone. (ENDO 2025, Press Release) DHEA and Sex Hormones in […]
Research Update: Skin Rejuvenation in Menopausal Women UsingHormone Therapy
A recent systematic review and meta-analysis published in the Journal of Menopausal Medicine explored the effects of Menopausal Hormone Therapy (MHT) on skin aging in women. The study aimed to evaluate whether MHT could positively influence skin elasticity, thickness, collagen content, and dryness in menopausal women aged 45–55 years. Key findings from the analysis, which […]
Breaking News: A Turning Point for Women’s Health and Hormone Therapy!
Is it time to revisit the recommendations for initiation of menopausal hormone therapy?
Progesterone’s Role in Sleep Quality
Study: Ogawa M, et al. Changes in Sleep Quality after Hormone Replacement Therapy with Micronized Progesterone in Japanese Menopausal Women. J Menopausal Med. 2025 Apr. PMCID: PMC12070122 Key Findings: A 2025 open-label study from Japan examined the effects of hormone replacement therapy (HRT) on sleep quality in peri- and postmenopausal women, focusing on the addition […]
