No One-Size-Fits-All: Individualizing Transdermal Estradiol Dosing
This month’s update turns to practical dosing guidance: a clinical review in Menopause makes the case that there is no single transdermal estradiol dose or target serum concentration that delivers symptom relief and bone protection for every woman. The authors argue that the optimal level for an individual varies with tissue sensitivity, the assay used […]
Marine Collagen Peptides
Marine collagen peptides are low-molecular-weight, hydrolyzed fragments of fish-derived Type I collagen that are readily absorbed and act as bioactive signaling peptides, supplying the amino acids (glycine, proline, hydroxyproline) used in connective-tissue synthesis. The most robust and consistent clinical evidence is dermatologic: pooled randomized trials show measurable improvements in skin hydration, elasticity, and wrinkle depth […]
The FDA Just Opened the Door Wider on Peptides. Here’s How to Make Them Work Even Better.
Something happened last week that a lot of you have been waiting for, and I want to celebrate it with you. On July 23 and 24, an FDA advisory committee voted to recommend adding several of the most popular peptides in our space, BPC-157, KPV, TB-500, and MOTS-c, to the list of substances that pharmacies […]
Bioidentical MHT Linked to Marked Mood Improvement in Peri- and Postmenopausal Women
A large real-world cohort study reinforces mood as a treatable target within BHRT: among 920 peri- and postmenopausal women at the UK’s largest specialist menopause clinic, Meno-D mood scores improved significantly over an average of 107 days following initiation or optimization of transdermal 17β-oestradiol — with progesterone or a levonorgestrel-releasing IUS, and with or without […]
Creatine Monohydrate
Creatine monohydrate is among the most extensively studied dietary supplements, functioning as a cellular energy substrate that regenerates ATP through the phosphocreatine system in tissues with high energy demand, including skeletal muscle and the brain. Its best-established clinical value is the preservation and accrual of lean body mass, muscle strength, and functional capacity, particularly when […]
Pygeum (Pygeum africanum / Prunus africana)
Pygeum africanum, derived from the bark of the African plum tree, is a lipophilic extract used for more than five decades in European urology to manage the lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH). Its active constituents — phytosterols, pentacyclic triterpenes, and ferulic acid esters — give it a pharmacology distinct from […]
Real-World Evidence Reinforces Safety and Effectiveness of Testosterone Therapy in Largest Cohort to Date
As Men’s Health Month brings renewed attention to androgen optimization, a newly published longitudinal cohort study of over 9,000 men treated for testosterone deficiency offers BHRT providers the most robust real-world dataset on testosterone therapy (TTh) outcomes to date. Published in the April 2026 issue of World Journal of Men’s Health, Clift and colleagues — […]
Early Hormone Therapy Significantly Reduces Osteoporosis and Fracture Risk in Postmenopausal Women
In this month’s update, a large real-world propensity-matched study presented at the 2026 Annual Meeting of the American Academy of Orthopaedic Surgeons found that postmenopausal women who initiated hormone replacement therapy within one year of their menopause diagnosis faced a significantly lower risk of osteoporosis over a five-year follow-up compared to non-users (OR 1.18 favoring […]
Melatonin
Melatonin is far more than a sleep supplement. Produced in the pineal gland, gut, immune cells, and within the mitochondria of virtually every cell, it functions as a master circadian regulator, potent antioxidant, and key participant in metabolic, immune, and reproductive health. For BHRT providers, its clinical significance extends well beyond sleep support: melatonin production […]
Hormone Therapy Amplifies Tirzepatide Weight Loss in Postmenopausal Women
A Mayo Clinic retrospective cohort study published in The Lancet Obstetrics, Gynaecology, & Women’s Health in January 2026 found that postmenopausal women using concurrent hormone therapy lost 35% more weight on tirzepatide than those on tirzepatide alone (–19.2% vs. –14.0% total bodyweight loss; p=0.0023), with 45% of hormone therapy users achieving ≥20% total bodyweight loss […]
